Motherhood is a wild ride.

From sleepless nights to learning your baby’s cries, it’s a season full of changes.

But what happens when those changes bring more than just exhaustion?

When they bring feelings of sadness, overwhelm, or even fear?

You’re not alone. Postpartum depression (PPD) and anxiety (PPA) are more common than people think.

The good news? Help is out there.

And for many moms, that includes medication.

But before we dive into this topic, let me be clear: I’m not a medical doctor.

I’m a therapist and a mom of four, here to share what I’ve learned from supporting other moms.

Any decisions about medication should always involve your medical provider.

How Medication Can Help with Postpartum Depression and Anxiety

PPD and PPA can feel heavy.

Medication isn’t a magic cure, but it can lighten the load.

It works by balancing chemicals in your brain that affect mood and anxiety.

For many moms, this means feeling more like themselves again—more energy, less racing thoughts, and the ability to enjoy the little things.

But medication is just one part of the puzzle.

Therapy, support groups, and self-care are also key players in recovery.

Common Types of Medication for PPD and PPA

SSRIs (Selective Serotonin Reuptake Inhibitors)
SSRIs are a common starting point.
They help increase serotonin, a brain chemical linked to mood.
Common SSRIs prescribed for postpartum depression and anxiety include:
- Sertraline (Zoloft): Often a first choice for breastfeeding moms.
- Escitalopram (Lexapro): Known for fewer side effects.
- Fluoxetine (Prozac): A long-time favorite in the mental health world.
SNRIs (Serotonin-Norepinephrine Reuptake Inhibitors)
If SSRIs aren’t quite right, SNRIs might be an option.
These work on serotonin and norepinephrine, another mood-related chemical. Examples include:
- Venlafaxine (Effexor XR)
- Duloxetine (Cymbalta)
Other Options
- Brexanolone (Zulresso): The first medication specifically for PPD. It’s given through an IV over 60 hours in a healthcare setting.
- Bupropion (Wellbutrin): Sometimes used for moms with low energy or motivation.

New mom talking to her doctor about SSRIs

Finding the Right Fit

Every mom is different, and so is every medication journey.

What works wonders for one person might not feel right for another.

This is where your provider’s expertise comes in. They’ll consider things like:

Whether you’re breastfeeding.
Your symptoms.
Your health history.

It’s not always a quick process.

Sometimes, finding the right medication (and dose) takes time. Be patient with yourself—it’s worth it.

What About Side Effects?

All medications come with potential side effects. Common ones for antidepressants include:

Stomach issues.
Sleep changes.
Decreased sexual desire.

Most side effects fade as your body adjusts. But if they’re persistent or severe, talk to your provider.

Never stop taking medication suddenly. Always work with your doctor to taper off if needed.

What If Medication Isn’t for You?

Medication isn’t the only path to healing.

Many moms find relief through therapy, exercise, mindfulness, and connecting with supportive people.

Medication is just one tool in the toolbox.

Encouragement from One Mom to Another

I know starting medication can feel scary.

There’s a lot of noise out there about what’s “best” for moms and babies.

But your mental health matters. A healthy mom is a gift to your family.

Mother talking to doctor about postpartum depression

Questions to Ask Your Provider

If you’re considering medication, here are a few questions to bring to your next appointment:

What are the benefits and risks of this medication?
How might it affect breastfeeding?
How long does it typically take to feel a difference?
Are there side effects I should watch for?

You’re Not Alone

Whether it’s through medication, therapy, or both, support is within reach.

It’s okay to ask for help. In fact, it’s one of the bravest things you can do.

Remember, I’m not a doctor. Always talk to a medical professional before starting or changing any medication.

Motherhood is hard, but you don’t have to do it alone. You’ve got this, mama.

With love and solidarity,

Are you struggling with postpartum mental health? Let’s connect!

Reach out for a free consultation today!

Schedule a free consult

Best Medication for Postpartum Depression and Anxiety

How Medication Can Help with Postpartum Depression and Anxiety